Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. No data are available regarding overdosage of Venofer in humans. https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Max Dose. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Modify Therapy/Monitor Closely. For liquid medications, also enter the value of the Medicine Concentration and choose . This drug is available at a higher level co-pay. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Applies only to oral form of both agents. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Applies only to oral form of both agents. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Accessed: 4/12/2011. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. Separate by 2 hr. Recommended dosing and infusion rates for PI. The primary endpoint was the proportion of patients with . Use Caution/Monitor. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Applies only to oral form of both agents. Applies only to oral form of both agents. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. *Repeat dose if iron deficiency anemia reoccurs. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Venofer treatment may be repeated if iron deficiency reoccurs. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Minor/Significance Unknown. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This may be helped by giving the medication more slowly or at a lower dose. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. Applies only to oral form of both agents. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. All Rights Reserved. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Minor/Significance Unknown. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Parenteral iron supplementation. You may report side effects to Health Canada at 1-866-234-2345. Administer Venofer only intravenously by slow injection or by infusion. Applies only to oral form of both agents. Applies only to oral form of both agents. In the text below the tool there is more information on how the iron deficit is calculated. Keep all medical and lab appointments. Separate dosing of tetracyclines from these products. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Ganzoni AM. World J Gastroenterol; 16(22): 27202725. We have found the lower dose to be better tolerated in the second half of gestation. Applies only to oral form of both agents. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Deferasirox chelates iron. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Use Caution/Monitor. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Treatment of anemia due to iron deficiency. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. The dosage of iron sucrose is expressed in mg of elemental iron. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. US residents can call their local poison control center at 1-800-222-1222. Applies only to oral form of both agents. Applies only to oral form of both agents. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Iron deficiency anemia is the type of anemia caused by iron depletion. Applies only to oral form of both agents. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Iron sucrose: 20 mg/mL. Iron Product. Canada residents can call a provincial poison control center. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. Minor/Significance Unknown. FERAHEME met the predefined criteria for non-inferiority to Venofer . Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Use Caution/Monitor. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Monitor for signs and symptoms of hypotension following each administration of Venofer. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Most Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. 1) Ganzoni AM. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes.
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